{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemworld.com\/?post_type=product&p=23378"},"modified":"2026-02-26T15:01:20","modified_gmt":"2026-02-26T15:01:20","slug":"escaline-hydrochloride","status":"publish","type":"product","link":"https:\/\/researchchemworld.com\/fr_be\/boutique\/presque-interdit\/escaline-hydrochloride\/","title":{"rendered":"Chlorhydrate d'escaline"},"content":{"rendered":"

Escaline Hydrochloride \u2013 Wetenschappelijke Productdocumentatie<\/strong><\/h3>\n

\ud83d\udd2c Sp\u00e9cifications chimiques<\/strong><\/h4>\n

Escaline (4-ethoxy-3,5-dimethoxyfenethylamine) hydrochloride is een semi-synthetisch phenethylaminederivaat dat structureel verwant is aan mescaline. Deze onderzoeksstof wordt bestudeerd vanwege zijn interessante farmacologische profiel.<\/p>\n

Param\u00e8tres de base :<\/em><\/p>\n

    \n
  • \n

    Nom de l'IUPAC<\/strong>: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethan-1-amine hydrochloride<\/p>\n<\/li>\n

  • \n

    Formule mol\u00e9culaire<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Poids mol\u00e9culaire<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    Puret\u00e9<\/strong>: \u226598% (HPLC-UV bij 280 nm)<\/p>\n<\/li>\n

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    Formulaire<\/strong>: Poudre cristalline blanche<\/p>\n<\/li>\n

  • \n

    Point de fusion<\/strong>: 243-245\u00b0C (ontleedt)<\/p>\n<\/li>\n

  • \n

    Solubilit\u00e9<\/strong>: 50 mg\/ml in water, 30 mg\/ml in methanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Applications scientifiques<\/strong><\/h4>\n
      \n
    1. \n

      Recherche neuropharmacologique<\/strong>:<\/p>\n

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      • \n

        5-HT\u2082A receptor binding studies (Ki = 120 nM)<\/p>\n<\/li>\n

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        Vergelijkende studies met mescaline en andere phenethylamines<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Recherche comportementale<\/strong>:<\/p>\n

          \n
        • \n

          Effecten op diergedrag in gecontroleerde settings<\/p>\n<\/li>\n

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          Dosis-responsrelaties bij zoogdier-modellen<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Metabolische studies<\/strong>:<\/p>\n

            \n
          • \n

            O-dealkylatie kinetiek onderzoek<\/p>\n<\/li>\n

          • \n

            Profil d'interaction du CYP2D6<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Aanbevolen Doseringen voor Onderzoek<\/strong><\/h4>\n

            Directives exp\u00e9rimentales :<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mod\u00e8le<\/th>\nDosage<\/th>\nAdministratieweg<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nCelcultuurmedium<\/td>\n<\/tr>\n
            Kleine dieren<\/td>\n1 \u00e0 5 mg\/kg<\/td>\nIntraperitoneaal<\/td>\n<\/tr>\n
            Primates<\/td>\n0,2-1 mg\/kg<\/td>\nOral<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Let op: Dosisafhankelijke effecten boven 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f Veiligheidsaspecten & Risico’s<\/strong><\/h4>\n
              \n
            1. \n

              Donn\u00e9es toxicologiques<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (muis, i.v.): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL\u00a0: 0,75 mg\/kg\/jour (\u00e9tude de 28 jours)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Bijwerkingenprofiel<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimale fysiologische effecten<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg: Sensorische modulatie<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potenti\u00eble hemodynamische effecten<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Interactions critiques<\/strong>:<\/p>\n

                    \n
                  • \n

                    Dangereux<\/strong>: MAO-remmers, serotonergische middelen<\/p>\n<\/li>\n

                  • \n

                    Risqu\u00e9<\/strong>: Vasoconstrictoren, antipsychotica<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Contr\u00f4le qualit\u00e9 et donn\u00e9es analytiques<\/strong><\/h4>\n
                      \n
                    • \n

                      Puret\u00e9 HPLC<\/strong>: 98,2% (C18-kolom, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Resterende oplosmiddelen<\/strong>: <0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Donn\u00e9es de stabilit\u00e9<\/strong>:<\/p>\n

                        \n
                      • \n

                        Houdbaarheid: 24 maanden bij -20\u00b0C<\/p>\n<\/li>\n

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                        Kamertemperatuur: 6 maanden (onder argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Questions de recherche fr\u00e9quemment pos\u00e9es<\/strong><\/h4>\n

                        Q1 : Quel est le m\u00e9canisme d\u2019action ?<\/strong>
                        \nA: Primaire werking als 5-HT\u2082A receptoragonist met secundaire effecten op dopaminerge systemen.<\/p>\n

                        Q2 : Comment la puissance se compare-t-elle \u00e0 celle de la mescaline ?<\/strong>
                        \nA: Ongeveer 1,5x hogere receptoraffiniteit maar langere werkingsduur (8-10 uur).<\/p>\n

                        Q3: Wat zijn optimale opslagcondities?<\/strong>
                        \nA: In amberkleurige vials onder inert gas bij -20\u00b0C.<\/p>\n

                        Q4: Zijn er genotoxische risico’s?<\/strong>
                        \nA: Ames-test negatief bij <1 mM, maar beperkte chromosoomtestdata.<\/p>\n

                        \ud83d\udccc Limites de la recherche<\/strong><\/h4>\n
                          \n
                        • \n

                          Donn\u00e9es limit\u00e9es sur l'exposition chronique<\/p>\n<\/li>\n

                        • \n

                          Onbekende effecten op neuroplasticiteit<\/p>\n<\/li>\n

                        • \n

                          M\u00e9tabolisme intersp\u00e9cifique variable<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Conclusie voor Wetenschappers<\/strong><\/h4>\n

                          Escaline hydrochloride biedt waardevolle mogelijkheden voor vergelijkend serotoninerg onderzoek, met een unieke combinatie van stabiliteit en werkingsduur. De hydrochloridevorm garandeert uitstekende oplosbaarheid voor laboratoriumtoepassingen.<\/p>\n

                          Belangrijke disclaimer: Dit product is uitsluitend bestemd voor wetenschappelijk onderzoek in geaccrediteerde laboratoria. Niet voor humaan gebruik of diagnostische toepassingen. Alle experimenten moeten worden uitgevoerd in overeenstemming met lokale regelgeving en ethische richtlijnen.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydrochloride eigenschappen<\/span><\/h3>\n

                          Synonyme:<\/strong> 3,5-dimethoxy-4-ethoxyphenethylamine hydrochloride
                          \nNum\u00e9ro CAS :<\/strong> 39201-82-6
                          \nFormule:<\/strong> 2-{3,5-dimethoxy-4-ethyloxyphenyl}ethan-1-amine hydrochloride
                          \nMasse molaire:<\/strong> 261.8 g\/mol
                          \nPuret\u00e9:<\/strong> >97%<\/p>","protected":false},"featured_media":29342,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/media\/29342"}],"wp:attachment":[{"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemworld.com\/fr_be\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}