{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemworld.com\/?post_type=product&p=23378"},"modified":"2026-02-26T15:01:20","modified_gmt":"2026-02-26T15:01:20","slug":"eskalin-hidroklorur","status":"publish","type":"product","link":"https:\/\/researchchemworld.com\/tr\/magaza\/neredeyse-yasaklandi\/eskalin-hidroklorur\/","title":{"rendered":"Eskalin hidroklor\u00fcr"},"content":{"rendered":"

Eskalin Hidroklor\u00fcr \u2013 Bilimsel \u00dcr\u00fcn Dok\u00fcmantasyonu<\/strong><\/h3>\n

\ud83d\udd2c Kimyasal \u00d6zellikler<\/strong><\/h4>\n

Eskalin (4-etoksi-3,5-dimetoksifenetilamin) hidroklor\u00fcr, yap\u0131sal olarak meskalin ile ili\u015fkili yar\u0131 sentetik bir fenetilamin t\u00fcrevidir. Bu ara\u015ft\u0131rma bile\u015fi\u011fi, ilgin\u00e7 farmakolojik profili nedeniyle incelenmektedir.<\/p>\n

Temel parametreler:<\/em><\/p>\n

    \n
  • \n

    IUPAC ad\u0131<\/strong>: 2-(4-etoksi-3,5-dimetoksifenil)etan-1-amin hidroklor\u00fcr<\/p>\n<\/li>\n

  • \n

    Molek\u00fcler form\u00fcl<\/strong>: C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molek\u00fcler a\u011f\u0131rl\u0131k<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    Safl\u0131k<\/strong>: \u226598% (280 nm'de HPLC-UV)<\/p>\n<\/li>\n

  • \n

    Bi\u00e7im<\/strong>: Beyaz kristal toz<\/p>\n<\/li>\n

  • \n

    Erime noktas\u0131<\/strong>: 243-245\u00b0C (ayr\u0131\u015f\u0131r)<\/p>\n<\/li>\n

  • \n

    \u00c7\u00f6z\u00fcn\u00fcrl\u00fck<\/strong>: Suda 50 mg\/ml, metanolde 30 mg\/ml<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Bilimsel Uygulamalar<\/strong><\/h4>\n
      \n
    1. \n

      N\u00f6rofarmakolojik ara\u015ft\u0131rma<\/strong>:<\/p>\n

        \n
      • \n

        5-HT\u2082A resept\u00f6r ba\u011flanma \u00e7al\u0131\u015fmalar\u0131 (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        Meskalin ve di\u011fer fenetilaminlerin kar\u015f\u0131la\u015ft\u0131rmal\u0131 \u00e7al\u0131\u015fmalar\u0131<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Davran\u0131\u015fsal ara\u015ft\u0131rma<\/strong>:<\/p>\n

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        • \n

          Kontroll\u00fc ortamlarda hayvan davran\u0131\u015flar\u0131 \u00fczerindeki etkiler<\/p>\n<\/li>\n

        • \n

          Memeli modellerde doz-tepki ili\u015fkileri<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabolik \u00e7al\u0131\u015fmalar<\/strong>:<\/p>\n

            \n
          • \n

            O-dealkilasyon kineti\u011fi \u00e7al\u0131\u015fmas\u0131<\/p>\n<\/li>\n

          • \n

            CYP2D6 etkile\u015fim profili<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Ara\u015ft\u0131rma \u0130\u00e7in \u00d6nerilen Dozajlar<\/strong><\/h4>\n

            Deneysel y\u00f6nergeler:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Model<\/th>\nDozaj<\/th>\n\u0130dare Yolu<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10-100 \u03bcM<\/td>\nH\u00fccre k\u00fclt\u00fcr\u00fc ortam\u0131<\/td>\n<\/tr>\n
            K\u00fc\u00e7\u00fck hayvanlar<\/td>\n1-5 mg\/kg<\/td>\n\u0130ntraperitoneal<\/td>\n<\/tr>\n
            Primatlar<\/td>\n0,2-1 mg\/kg<\/td>\nA\u011f\u0131zdan<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Not: 3 mg\/kg'\u0131n \u00fczerinde doza ba\u011fl\u0131 etkiler*<\/p>\n

            \u26a0\ufe0f G\u00fcvenlik Y\u00f6nleri ve Riskler<\/strong><\/h4>\n
              \n
            1. \n

              Toksikolojik veriler<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (fare, iv): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/g\u00fcn (28 g\u00fcnl\u00fck \u00e7al\u0131\u015fma)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Yan etki profili<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimum fizyolojik etkiler<\/p>\n<\/li>\n

                • \n

                  2-6 mg\/kg: Duyusal mod\u00fclasyon<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potansiyel hemodinamik etkiler<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritik etkile\u015fimler<\/strong>:<\/p>\n

                    \n
                  • \n

                    Tehlikeli<\/strong>: MAO inhibit\u00f6rleri, serotoninerjik ajanlar<\/p>\n<\/li>\n

                  • \n

                    Riskli<\/strong>: Vazokonstrikt\u00f6rler, antipsikotikler<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kalite Kontrol ve Analitik Veriler<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC safl\u0131\u011f\u0131<\/strong>: 98.2% (C18 s\u00fctunu, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Art\u0131k \u00e7\u00f6z\u00fcc\u00fcler<\/strong>: <0.1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Kararl\u0131l\u0131k verileri<\/strong>:<\/p>\n

                        \n
                      • \n

                        Raf \u00f6mr\u00fc: -20\u00b0C'de 24 ay<\/p>\n<\/li>\n

                      • \n

                        Oda s\u0131cakl\u0131\u011f\u0131: 6 ay (argon alt\u0131nda)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 S\u0131k\u00e7a Sorulan Ara\u015ft\u0131rma Sorular\u0131<\/strong><\/h4>\n

                        S1: Etki mekanizmas\u0131 nedir?<\/strong>
                        \nA: Birincil etkisi 5-HT\u2082A resept\u00f6r agonisti olarak, ikincil etkisi ise dopaminerjik sistemler \u00fczerindedir.<\/p>\n

                        S2: Etkisi meskalinle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda nas\u0131ld\u0131r?<\/strong>
                        \nA: Resept\u00f6r afinitesi yakla\u015f\u0131k 1,5 kat daha y\u00fcksek ancak etki s\u00fcresi daha uzundur (8-10 saat).<\/p>\n

                        S3: Optimum depolama ko\u015fullar\u0131 nelerdir?<\/strong>
                        \nA: -20\u00b0C'de inert gaz alt\u0131nda kehribar renkli \u015fi\u015felerde.<\/p>\n

                        S4: Genotoksik riskler var m\u0131d\u0131r?<\/strong>
                        \nA: Ames testi <1 mM'de negatif, ancak kromozom testi verileri s\u0131n\u0131rl\u0131.<\/p>\n

                        \ud83d\udccc Ara\u015ft\u0131rman\u0131n s\u0131n\u0131rlamalar\u0131<\/strong><\/h4>\n
                          \n
                        • \n

                          Kronik maruziyete ili\u015fkin s\u0131n\u0131rl\u0131 veri<\/p>\n<\/li>\n

                        • \n

                          N\u00f6roplastisite \u00fczerindeki bilinmeyen etkiler<\/p>\n<\/li>\n

                        • \n

                          De\u011fi\u015fken t\u00fcrler aras\u0131 metabolizma<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Bilim \u0130nsanlar\u0131 \u0130\u00e7in Sonu\u00e7<\/strong><\/h4>\n

                          Eskalin hidroklor\u00fcr, benzersiz stabilite ve uzun \u00f6m\u00fcrl\u00fcl\u00fck kombinasyonuyla kar\u015f\u0131la\u015ft\u0131rmal\u0131 serotonin ara\u015ft\u0131rmalar\u0131 i\u00e7in de\u011ferli f\u0131rsatlar sunar. Hidroklor\u00fcr formu, laboratuvar uygulamalar\u0131 i\u00e7in m\u00fckemmel \u00e7\u00f6z\u00fcn\u00fcrl\u00fck sa\u011flar.<\/p>\n

                          \u00d6nemli uyar\u0131: Bu \u00fcr\u00fcn yaln\u0131zca akredite laboratuvarlarda bilimsel ara\u015ft\u0131rma ama\u00e7l\u0131d\u0131r. \u0130nsan kullan\u0131m\u0131 veya te\u015fhis uygulamalar\u0131 i\u00e7in uygun de\u011fildir. T\u00fcm deneyler yerel y\u00f6netmeliklere ve etik kurallara uygun olarak ger\u00e7ekle\u015ftirilmelidir.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Eskalin hidroklor\u00fcr \u00f6zellikleri<\/span><\/h3>\n

                          E\u015f anlaml\u0131s\u0131:<\/strong> 3,5-dimetoksi-4-etoksifenetilamin hidroklor\u00fcr
                          \nCAS Numaras\u0131:<\/strong> 39201-82-6
                          \nForm\u00fcl:<\/strong> 2-{3,5-dimetoksi-4-etiloksifenil}etan-1-amin hidroklor\u00fcr
                          \nMol k\u00fctlesi:<\/strong> 261,8 g\/mol
                          \nSafl\u0131k:<\/strong> >97%<\/p>","protected":false},"featured_media":29342,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/media\/29342"}],"wp:attachment":[{"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemworld.com\/tr\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}