5-甲氧基-DMT游离碱

5-MeO-DMT Freebase – Scientific Product Documentation

一般描述

5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) freebase is a naturally occurring tryptamine with a potent psychoactive profile, found in various plants and animal secretions. In its freebase form, it offers superior volatility for certain research methods, making it valuable for pharmacological and neuroscience studies.

技术规格

科学应用

1. Neuropharmacological Research

• Serotonergic Action:  Potent 5-HT₁ₐ/₂ₐ agonist, relevant for studies of consciousness modulation.

• EEG/fMRI studies:  Investigation of acute effects on brain wave patterns (e.g. gamma oscillations).

• Neuroplasticity:  Possible BDNF-enhancing effects (in animal models).

2. Metabolic & Toxicological Studies

• MAO-dependent metabolism:  Investigation of CYP2D6 and MAO-A degradation pathways.

• Dose-dependent toxicity:  Determination of safety margins in cell cultures.

3. Comparative Pharmacology

• Compared to DMT:  Higher potency but shorter duration of action (15-30 min when inhaled).

• Compared to psilocybin:  Differences in receptor affinity and subjective effects.

实验指南

Recommended Concentrations (In Vitro)

安全协议

• Personal Protection:  Lab coat, nitrile gloves, safety glasses, FFP2 mask when handling powder.

• Ventilation:  Always work under a fume cupboard when heating/evaporating.

• 贮存：  In amber vials, under argon, at -20°C (long term).

稳定性和存储

• 保质期：

  • Room temperature: <24 hours in solution.

  • 4°C: Stable for 3 days (under argon).

  • -20°C: >6 months (unchanged purity).

• Degradation products:

  • Oxidation to indole derivatives (check by TLC/HPLC).

Analytical Certification

Each batch includes:

1. HPLC-UV色谱图  (λ=280 nm, C18 column)

2. GC-MS confirmation  (characteristic fragments: m/z 174, 160)

3. Residual solvent analysis  （≤500 ppm）

4. Water content  （卡尔费休，<1%）

Legal Status (Netherlands)

• Opium Act:  Not explicitly regulated, but possibly under analogous legislation.

• Legislation:  A licence is required for scientific institutions (Appendix 2, Opium Act).

• Export restrictions:  CITES listing (due to natural sources such as  因西利乌斯·阿尔瓦里乌斯 ).

常见问题 (FAQ)

Q1: What is the difference between freebase and fumaric acid salt?
A: Freebase is more volatile (suitable for evaporation experiments), while fumaric acid salt is more stable in solutions.

Q2: How is 5-MeO-DFT detected in toxicology screens?
A: Identifiable by:

• LC-MS/MS（母离子 m/z 219 → 子离子 m/z 174）

• Immunoassays: Cross-reactivity with some DMT tests (≤30%).

Q3: Are there any known pharmacokinetic interactions?
一个：  Dangerous combinations:

• MAO inhibitors (risk of serotonin syndrome).

• SSRIs (reduced efficacy due to competition).

Q4：废弃物如何处理？
A: Inactivate with:

1. Dilute hydrochloric acid (0.1M) for neutralization.

2. Absorption with activated carbon.

3. 处置为  危险化学废物  (UN number: 3249).

参考及联系方式

Key publications:

• 萨拉，S.（2007）。 “DMT 和 5-MeO-DMT：早期人类研究”。

• 乌索格等人。 （2021）。 “5-MeO-DMT 的精神药理学”。

This product is intended solely for legitimate scientific research. Not for human or veterinary use. Users must comply with all local regulations.